Some azodyes as corrosion inhibitors for iron in HCl solution

The inhibitor effect of the quinazol-4-one derivatives on the corrosion of iron in hydrochloric acid solution was investigated. Polarization curves indicated that these compounds act as mixed type inhibitors, but the cathode is more preferentially polarized. The effect of structural changes in these compounds on their inhibition efficiency has been studied. The inhibitors appear to function through general adsorption following the Langmuir adsorption isotherm. Results indicate that the rate of corrosion of iron increases with increasing temperature over the range 27-50°C both in absence and in the presence of inhibitors. Some thermodynamic functions were also computed and are discussed

Multi-parametric cell profiling with a CMOS quad-modality cellular interfacing array for label-free fully automated drug screening

Cells are complex systems with concurrent multi-physical responses, and cell physiological signals are often encoded with spatiotemporal dynamics and further coupled with multiple cellular activities. However, most existing electronic sensors are only single-modality and cannot capture multi-parametric cellular responses. In this paper, a 1024-pixel CMOS quad-modality cellular interfacing array that enables multi-parametric cell profiling for drug development is presented. The quad-modality CMOS array features cellular impedance characterization, optical detection, extracellular potential recording, and biphasic current stimulation. The fibroblast transparency and surface adhesion are jointly monitored by cellular impedance and optical sensing modalities for comprehensive cell growth evaluation. Simultaneous current stimulation and opto-mechanical monitoring based on cardiomyocytes are demonstrated without any stimulation/sensing dead-zone. Furthermore, drug dose-dependent multi-parametric feature extractions in cardiomyocytes from their extracellular potentials and opto-mechanical signals are presented. The CMOS array demonstrates great potential for fully automated drug screening and drug safety assessments, which may substantially reduce the drug screening time and cost in future new drug development.ISSN:1473-0197ISSN:1473-018

Book of Abstracts: 2019 Health Equity Summer Research Summit Organized by the Center of Excellence in Health Equity, Training and Research, Baylor College of Medicine, Houston, Texas 77030, USA on June 18th, 2019

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